Isosorbide dinitrate - oral

Patient Medicine Information
Why do I need this medicine?
Isosorbide dinitrate is used to prevent and treat angina (chest pain).

This medicine may also be used to manage certain types of heart failure.
How do I take this medicine?
Take Isosorbide dinitrate exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Try to take it at the same time each day.

This medicine is available as conventional or prolonged-release tablet.

If you are taking the prolonged-release type of tablet (usually labelled as "Retard Tablet"), swallow it whole with a glass of water. Do not divide, chew, or crush the tablet.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the type and severity of your condition, and your response to this medicine.

This medicine must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it suddenly as this may worsen your condition.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Alert your doctor if you have the following conditions:
  • other heart problems e.g. heart valve problems, build up of fluid under the heart surface, inflammation of the heart surface, chest pain caused by an enlarged heart muscle, have had a heart attack
  • increased pressure around the brain caused by head trauma or bleeding in the brain
  • anaemia (low red blood cell count in the body)
  • very low blood pressure
  • low blood volume in the body
  • circulatory failure (a condition wherein the blood has stopped circulating properly in the body)
as Isosorbide dinitrate may not be suitable for you.

Do not take Isosorbide dinitrate with medicines used to treat impotence and medicine used to treat high blood pressure in the blood vessels leading to the lungs. Please see the section "Can I take this with other medicines?" below for more information.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • glaucoma (increased pressure in the eye)
  • underactive thyroid gland
  • hypothermia (low body temperature)
  • malnutrition
  • abnormally low level of oxygen in the blood
  • impaired gas exchange caused by a lung or heart disease
  • severe liver disease
  • severe kidney disease
Let your doctor know if you are pregnant or breastfeeding.

Be sure to check with your doctor or pharmacist before giving Isosorbide dinitrate to the elderly. Elderly people may be more sensitive to the side effects.
What side effects could I experience?
Isosorbide dinitrate may cause any of the following side effects: nausea, vomiting, dizziness, sleepiness, rash, reddening of the skin, headache, and fast and irregular heartbeat.

This medicine may cause your blood pressure to fall suddenly when you get up from a sitting or lying down position and you may feel giddy. To minimise this problem, stand up slowly.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Do not take Isosorbide dinitrate with the following medicines:
  • medicines used to treat impotence e.g. sildenafil, tadalafil, vardenafil
  • riociguat (medicine used to treat high blood pressure in the blood vessels leading to the lungs)
Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines for high blood pressure e.g. atenolol, nifedipine, losartan, captopril
  • medicines to treat depression e.g. isocarboxazid, amitriptyline
  • medicines for mood disorders e.g. chlorpromazine
This list does not include all medicines that may interact with this medicine.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on isosorbide dinitrate - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by
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