Increased risk of adverse reactions w/ strong (eg, itraconazole, clarithromycin), moderate (eg, fluconazole, verapamil), or weak (eg, chlorzoxazone, ranitidine) CYP3A inhibitors. Reduced efficacy w/ strong (eg, rifampin, carbamazepine, St. John's wort) or moderate (eg, bosentan, efavirenz, etravirine, modafinil) CYP3A inducers. Greater negative impact on postural stability & memory w/ alcohol. Reduced efficacy of CYP2B6 substrates (eg, bupropion, methadone).